Oral muscles are progressively affected in Duchenne muscular dystrophy: implications for dysphagia treatment
van den Engel-Hoek L, Erasmus CE, Hendriks JC, Geurts AC, Klein WM, Pillen S, Sie LT, de Swart BJ, de Groot IJ.
J Neurol. 2013. 260(5):1295-303.
Dysphagia is reported in advanced stages of Duchenne muscular dystrophy (DMD). Authors aimed to describe the dysphagia in consecutive stages and to assess the underlying mechanisms of dysphagia in DMD, in order to develop mechanism based recommendations for safe swallowing. In this cross-sectional study, participants were divided into: early and late ambulatory stage (n = 6), early non-ambulatory stage (n = 7), and late non-ambulatory stage (n = 11). MFM was used to describe the patient population at inclusion.
Conclusion of authors are, in case of swallowing problems in DMD, based on the disturbed mechanisms of swallowing, it is suggested to (1) adjust meals in terms of less solid food, and (2) drink water after meals to clear the oropharyngeal area.
Keywords: Duchenne muscular dystrophy, Dysphagia, Oral muscles, Ultrasound , Video fluoroscopic swallow study, Surface electromyography
Articles dans les revues scientifiques
Impaired Mandibular Function in Spinal Muscular Atrophy Type II: Need for Early Recognition
van Bruggen HW, van den Engel-Hoek L, van der Pol WL, de Wijer A, de Groot IJ, Steenks MH. J Child Neurol. Nov 2011. 26: 1392 - 1396. The aim of the study is to assess mandibular function in young patients with spinal muscular atrophy type II. The mandibular function...
Idebenone for the treatment of Duchenne muscular dystrophy (Protocol)
Geng J, Dong J, Jiang K, Shen L, Wu T, Ni H, Shi LL, Wang G, Wu H. The Cochrane Library 2011. Description of a protocol aiming at assessing efficacy of ibedenone on muscle strength, muscle function, lung function, cardiac function and quality of life for patients with...
High-frequency, low-intensity vibrations increase bone mass and muscle strength in upper limbs, improving autonomy in disabled children
Reyes ML, Hernandez M, Holmgren LJ, Sanhueza E, Escobar RG. J Bone Miner Res, 2011. 26(8): 1759-66. The main objective of this study was to evaluate the efficacy and safety of high-frequency, low-magnitude vibration, in patients with disabilities. 55 children were a...
Motor Function Measure Scale (MFM): New Instrument for Follow-Up Brazilian Patients with Neuromuscular Disease
Iwabe C, Nucci A, Pfeilsticker BHM, Magna LA. Muscular Dystrophy ed.Croacia : Intech. 2012. 303-320. Book chapter presenting the validation and applicability of the MFM Portuguese version.Link Articles dans les revues scientifiques
Recombinant human acid alpha-glucosidase (rhGAA) in adult patients with severe respiratory failure due to Pompe disease
Orlikowski D, Pellegrini N, Prigent H, Laforêt P, Carlier R, Carlier P, Eymard B, Lofaso F, Annane D. Neuromuscul Disord. 2011. 21(7):477-82. This open-label prospective exploratory study investigated the effect of 12 months of recombinant enzyme replacement therapy...
Upper limb function in adults with Duchenne muscular dystrophy
Bartels G, Pangalila RF, Bergen MP, Cobben NAM, Stam HJ, Roebroeck ME. J Rehabil Med 2011. 43(9) : 770-5. This study illustrates a large variability in upper limb function in adult patients with Duchenne muscular dystrophy, and identifies muscle strength and range of...