What Can We Learn From Assisted Bicycle Training in a Girl With Dystrophinopathy? A Case Study
Huijben J, Jansen M, Ginjaar IN, Lammens M, van Putten M, van Alfen N, de Groot I.
J Child Neurol. 2015. 30(5),659-63.
Case study of a 9-year-old ambulatory girl with dystrophinopathy due to a mosaic translocation mutation participated in dynamic training. The girl trained at home, first 15 minutes with her legs and then 15 minutes with her arms, 5 times a week, for 24 weeks. This case study showed that the training was feasible and safe. In addition, no physical deterioration occurred during the training period: the MFM and the “Assisted 6-Minute Cycling Test” results remained stable. Slight improvements in quantitative muscle ultrasound intensity were found, indicating less fatty infiltration in the muscles. These results suggest that physical training could be beneficial in females with dystrophinopathy who express low levels of dystrophin.
Keywords: Duchenne muscular dystrophy, female, Becker muscular dystrophy, exercise, assisted bicycle training, dystrophinopathy
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