Quantitative muscle MRI to follow up late onset Pompe patients: a prospective study

Figueroa-Bonaparte S, Llauger J, Segovia S, Belmonte I, Pedrosa I, Montiel E, Montesinos P, Sánchez-González J, Alonso-Jiménez A, Gallardo E, Illa I, Díaz-Manera J ; Spanish Pompe group.
Sci Rep. 2018. 18;8(1):10898. 
In this study, 32 Late onset Pompe disease patients (22 symptomatic and 10 asymptomatic) underwent muscle MRI using 3-point Dixon at inclusion and after one year, and were evaluated with several
motor function tests, among them the MFM-20, and patient-reported outcome measures.
Authors concluded that qMRI is a very efficient tool for demonstrating the muscular condition of Pompe patients from the morphological point of view, and to monitor symptomatic and asymptomatic
patients.

PubMed link 

Articles in scientific journals

Protocol for a phase II, monocentre, double-blind, placebo-controlled, cross-over trial to assess efficacy of pyridostigmine in patients with spinal muscular atrophy types 2-4 (SPACE trial)

Stam M, Wadman RI, Wijngaarde CA, Bartels B, Asselman FL, Otto LAM, Goedee HS, Habets LE, de Groot JF, Schoenmakers MAGC, Cuppen I, van den Berg LH, van der Pol WL. BMJ Open. 2018. 30;8(7):e019932.  Protocol of the "SPACE" in wich MFM is used as an outcome measure....

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