Evaluation of Speed-Accuracy Trade-Off in a Computer Task to Identify Motor Difficulties in Individuals With Duchenne Muscular Dystrophy – A Cross-Sectional Study
da Silva TD, Ribeiro-Papa DC, Coe S, Malheiros SRP, Massetti T, Meira Junior CM, Nicolai Ré AH, Collett J, Monteiro CBM, Dawes H.
Res Dev Disabil. 2020. 96:103541.
The aim of the study was to evaluate movement time during a task at various levels of difficulty and to verify whether the level of difficulty affects the speed and/or accuracy during the task.
Multiple regression analysis indicated that age and motor performance assessed by the MFM-total scale can predict the increase in movement time from one ID to another.
The study also highlited a significant correlations between values of r2 (a coefficient of determination that evaluates the degree of agreement between model predictions and the dependent variable) and the MFM-D3 score, indicating that the higher the distal functioning of the upper limbs, the lower the variability of the movement time.
Articles in scientific journals
Disease duration and disability in dysfelinopathy can be described by muscle imaging using heatmaps and random forests.
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Two-minute versus 6-minute walk distances during 6-minute walk test in neuromuscular disease: Is the 2-minute walk test an effective alternative to a 6-minute walk test?
Witherspoon JW, Vasavada R, Logaraj RH, Waite M, Collins J, Shieh C, Meilleur K, Bönnemann C, Jain M. Eur J Paediatr Neurol. 2019. 23 (1), 165-170. The primary objective of this study is to establish the utility of the 2-min walk test (2MWT) in patients with...
Correlation of phenotype with genotype and protein structure in RYR1-related disorders
Todd JJ, Sagar V, Lawal TA, Allen C, Razaqyar MS, Shelton MS, Chrismer IC, Zhang X, Cosgrove MM, Kuo A, Vasavada R, Jain MS, Waite M, Rajapakse D, Witherspoon JW, Wistow G, Meilleur KG. J Neurol. 2018. 265(11), 2506-2524. Variants in the skeletal muscle ryanodine...
Nusinersen in spinal muscular atrophy type 1 patients older than 7 months: A cohort study
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Functional assessment tools in children with Pompe disease: A pilot comparative study to identify suitable outcome measures for the standard of care
Ricci F, Brusa C, Rossi F, Rolle E, Placentino V, Berardinelli A, Pagliardini V, Porta F, Spada M, Mongini T. Eur J Paediatr Neurol 2018. 22(6),1103-1109. Progression of Pompe disease was evaluated in 8 young patients. From the results of the study, the authors...
Protocol for a phase II, monocentre, double-blind, placebo-controlled, cross-over trial to assess efficacy of pyridostigmine in patients with spinal muscular atrophy types 2-4 (SPACE trial)
Stam M, Wadman RI, Wijngaarde CA, Bartels B, Asselman FL, Otto LAM, Goedee HS, Habets LE, de Groot JF, Schoenmakers MAGC, Cuppen I, van den Berg LH, van der Pol WL. BMJ Open. 2018. 30;8(7):e019932. Protocol of the "SPACE" in wich MFM is used as an outcome measure....